Mouse FAS/Cd95 ELISA Kit PicoKine®

SKU: EK0336

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Mouse

Applications: ELISA

Application Details:

Gene Name: FAS

Specificity: Natural and recombinant mouse FAS

Background: Fas, also known as APO-1, CD95 and TNFRSF6, is a member of the nerve growth factor (NGF)/tumour necrosis factor (TNF) receptor superfamily and mediates apoptosis. The nucleotide sequence of the cDNAs reveales that the molecule coding for the Fas antigen determinant is a 319 amino acid polypeptide with a single transmembrane domain. The extracellular domain is rich in cysteine residue, and shows a similarity to that of human tumor necrosis factor receptors, human nerve growth factor receptor, and human B cell antigen CD40. The APO-1 antigen as defined by the mouse monoclonal antibody anti-APO-1 is previously found to be expressed on the cell surface of activated human T and B lymphocytes and a variety of malignant human lymphoid cell lines. The APO-1 antigen is found to be a membrane glycoprotein of 48-kDa. Fas antigen is expressed and functional on papillary thyroid cancer cells and this may have potential therapeutic significance. Fas can play a role as an inducer of both neurite growth in vitro and accelerates recovery after nerve injury in vivo.

Immunogen: Expression system for standard: NS0; Immunogen sequence: Q22-R169

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Uniprot ID: P25446

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 14102

Protein Name: Tumor necrosis factor receptor superfamily member 6

Gene Full Name: Fas cell surface death receptor

Synonyms: ALPS1A; APO 1; Apo 1 antigen; APT1; CD95; FAS; FAS/CD95; FAS1; FASLG receptor; FASTM; TNFRSF6