Mouse Estrogen Receptor, ER ELISA Kit

SKU: E1480Mo

Size:96 Tests-1 Kit

Background:Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3.

Research_area:Others

Applications:ELISA

Target_protein:ESR1

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.27ng/ml

Detection range:0.5-100ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Estrogen Receptor

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P19785

MASS(Da):66,955

GeneID:13982

Synonyms:ER;ER-alpha;ESR 1;ESR1;Estradiol receptor;Estrogen receptor;Nuclear receptor subfamily 3 group A member 1

Gene names:ESR1

Standard solution:128ng/ml