Mouse Elav-like Protein 1, ELAVL1 ELISA Kit

SKU: E2047Mo

Size:96 Tests-1 Kit

Background:RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (PubMed: 24394384). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (By similarity). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (PubMed: 21402775). Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR (PubMed: 27616329).

Research_area:Others

Applications:ELISA

Target_protein:ELAVL1

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:7.75ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Elav-Like Protein 1

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P70372

MASS(Da):36,169

GeneID:15568

Synonyms:ELAVL 1;ELAVL1;Elav-like generic protein;ELAV-like protein 1;Hu-antigen R;HuR;MelG

Gene names:ELAVL1

Standard solution:3200ng/L