Mouse CD30L ELISA Kit PicoKine®

SKU: EK0572

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Mouse

Applications: ELISA

Application Details:

Gene Name: TNFSF8

Specificity: Natural and recombinant mouse CD30L

Background: The human CD30L (CD153) gene is located at 9q33. It contains 4 exons and spans more than 17.1 kb. CD153 is expressed on the surface of B cells and this expression is upregulated upon CD154 (CD40LG), IL4, and B-cell receptor engagement. In these cells, engagement of CD153 by T cell CD30 inhibits immunoglobulin class switch recognition as well as IgG, IgA, and IgE production, suggesting that thisreverse signaling modulates the CD154-dependent switching of B cells into the pool producing IgG, IgA, and IgE. Additionally, recombinant human CD30L enhanced the proliferation of CD3 -activated T cells, but induced differential responses, including cell death, in several CD30-positive lymphoma-derived cell lines.The standard product used in this kit is recombinant mouse CD30L with the molecular mass of 30-45KDa.

Immunogen: Expression system for standard: NS0; Immunogen sequence: Q68-D239

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Reference:

Uniprot ID: P32972

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 21949

Protein Name: Tumor necrosis factor ligand superfamily member 8

Gene Full Name: tumor necrosis factor (ligand) superfamily, member 8

Synonyms: TNF superfamily member 8; CD153; CD30L; CD30LG; TNLG3A; TNFSF8