Mouse Cathepsin L1, CTSL1 ELISA Kit

SKU: E1911Mo

Size:96 Tests-1 Kit

Background:Thiol protease important for the overall degradation of proteins in lysosomes (Probable). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (PubMed: 12782676). In neuroendocrine chromaffin cells secretory vesicles, catalyzes the prohormone proenkephalin processing to the active enkephalin Peptide neurotransmitter (PubMed: 12869695). In thymus, regulates CD4(+) T cell positive selection by generating the major histocompatibility complex class II (MHCII) bound Peptide ligands presented by cortical thymic epithelial cells (PubMed: 12021314). Also mediates invariant chain processing in cortical thymic epithelial cells (PubMed: 9545226). Major elastin-degrading enzyme at neutral pH. Accumulates as a mature and active enzyme in the extracellular space of antigen presenting cells (APCs) to regulate degradation of the extracellular matrix in the course of inflammation (PubMed: 12417635). Secreted form generates endostatin from COL18A1 (PubMed: 10716919). Critical for cardiac morphology and function (PubMed: 11972068). Plays an important role in hair follicle morphogenesis and cycling, as well as epidermal differentiation (PubMed: 12163394). Required for maximal stimulation of steroidogenesis by TIMP1 (By similarity).

Research_area:Signal Transduction

Applications:ELISA

Target_protein:CTSL

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:14.36ng/L

Detection range:30-9000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Cathepsin L1

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P06797

MASS(Da):37,547

GeneID:13039

Synonyms:Cathepsin L;Cathepsin L heavy chain;Cathepsin L light chain;Cathepsin L1;CTSL;Major excreted protein;MEP;p39 cysteine proteinase;Procathepsin L;

Gene names:CTSL

Standard solution:9600ng/L