Mouse Caspase 3, CASP3 ELISA Kit

SKU: E1513Mo

Size:96 Tests-1 Kit

Background:Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes (By similarity). Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress (PubMed: 12124386).

Research_area:Cell Biology; Cancer; Metabolism

Applications:ELISA

Target_protein:CASP3

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.023ng/ml

Detection range:0.05-10ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Caspase 3

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P70677

MASS(Da):31475

GeneID:12367

Synonyms:Apopain;CASP 3;CASP3;CASP-3;Caspase-3;Caspase-3 subunit p12;Caspase-3 subunit p17;CPP-32;Cysteine protease CPP32;LICE;Protein Yama;SCA-1;SREBP cleavage activity 1;

Gene names:CASP3

Standard solution:12.8ng/ml