Mouse ATPase, Ca++ Transporting, Plasma Membrane 2,ATP2B2 ELISA KIT

SKU: E0765Mo

Size:96 Tests-1 Kit

Background:ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels in specialized cells of cerebellar circuit and vestibular and cochlear systems (PubMed:17234811, PubMed:9668038). Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment. Has fast activation and Ca(2+) clearance rate suited to control fast neuronal Ca(2+) dynamics (PubMed:17409239, PubMed:20083513). At parallel fiber to Purkinje neuron synapse, mediates presynaptic Ca(2+) efflux in response to climbing fiber-induced Ca(2+) rise. Provides for fast return of Ca(2+) concentrations back to their resting levels, ultimately contributing to long-term depression induction and motor learning (PubMed:17409239, PubMed:20083513). Plays an essential role in hearing and balance. In cochlear hair cells, shuttles Ca(2+) ions from stereocilia to the endolymph and dissipates Ca(2+) transients generated by the opening of the mechanoelectrical transduction channels. Regulates Ca(2+) levels in the vestibular system, where it contributes to the formation of otoconia (PubMed:9668038) (By similarity). Regulates Ca(2+) signaling through dissipation of Ca(2+) transients generated by store-operated channels (By similarity). In lactating mammary gland, allows for the high content of Ca(2+) ions in the milk (PubMed:15302868). {ECO:0000250|UniProtKB:Q01814, ECO:0000269|PubMed:15302868, ECO:0000269|PubMed:17234811, ECO:0000269|PubMed:17409239, ECO:0000269|PubMed:20083513, ECO:0000269|PubMed:9668038}.

Research_area:

Applications:ELISA

Target_protein:Atp2b2

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.11ng/ml

Detection range:0.19-12ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:ATPase, Ca++ Transporting, Plasma Membrane 2

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9R0K7

MASS(Da):132588

GeneID:11941

Synonyms:Atp2b2 Pmca2

Gene names:Atp2b2

Standard solution:24ng/ml