Mouse A Disintegrin and Metalloproteinase with Thrombospondin Motifs 5, ADAMTS5 ELISA Kit

SKU: E1580Mo

Size:96 Tests-1 Kit

Background:Metalloproteinase that plays an important role in connective tissue organization, development, inflammation and cell migration. Extracellular matrix (ECM) degrading enzyme that shows proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including ACAN, VCAN, BCAN and NCAN. Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its VCAN remodeling properties. Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration (PubMed: 23233679). Participates in the development of brown adipose tissue and browning of white adipose tissue (PubMed: 28702327). Plays an important role for T-lymphocyte migration from draining lymph nodes following viral infection (PubMed: 27855162).

Research_area:Cell Biology

Applications:ELISA

Target_protein:ADAMTS5

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.113ng/mL

Detection range:0.2-70ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:A Disintegrin and Metalloproteinase with Thrombospondin Motifs 5

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9R001

MASS(Da):101,844

GeneID:23794

Synonyms:A disintegrin and metalloproteinase with thrombospondin motifs 5;ADAMTS 5;ADAM-TS 5;ADAMTS5;ADAMTS-5;ADAM-TS5;ADMP-2;Aggrecanase-2;Implantin;

Gene names:ADAMTS5

Standard solution:80ng/mL