MNDA Antibody - Cat. #: CSB-PA192245

SKU: CSB-PA192245

Size :100ul

Clone Number:

Aliases:MNDA antibody; MNDA_HUMAN antibody; Myeloid cell nuclear differentiation antigen antibody; OTTHUMP00000024384 antibody; PYHIN3 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P41218

Immunogen:Synthesized peptide derived from C-terminal of Human MNDA.

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB; WB:1:500-1:3000

Background:The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons.

Briggs J.A., J. Cell. Biochem. 49:82-92(1992).
The MGC Project Team; Genome Res. 14:2121-2127(2004).
Burrus G.R., J. Cell. Biochem. 48:190-202(1992).

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:MNDA

Research Areas:Immunology;Stem cells