MKRN1 Rabbit Polyclonal Antibody

SKU: BT-AP03621

Size:100μL

Background:This gene encodes a protein that belongs to a novel class of zinc finger proteins. The encoded protein functions as a transcriptional co-regulator| and as an E3 ubiquitin ligase that promotes the ubiquitination and proteasomal degradation of target proteins. The protein encoded by this gene is thought to regulate RNA polymerase II-catalyzed transcription. Substrates for this protein's E3 ubiquitin ligase activity include the capsid protein of the West Nile virus and the catalytic subunit of the telomerase ribonucleoprotein. This protein controls cell cycle arrest and apoptosis by regulating p21| a cell cycle regulator| and the tumor suppressor protein p53. Pseudogenes of this gene are present on chromosomes 1| 3| 9| 12 and 20| and on the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms.

Research_area:Cell biology; Epigenetics and nuclear signaling

Target_protein:MKRN1

applications:WB

Reactivity:Human, Mouse

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:MKRN1

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):53020

UniProt accession:Human: Q9UHC7; Mouse: Q9QXP6

Synonyms:MKRN1

GeneID:Human: 23608