MICAL2 antibody , Cat. # FNab05178

SKU: FNab05178

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin and regulates the SRF signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA.

Immunogen:microtubule associated monoxygenase, calponin and LIM domain containing 2

Synonyms:KIAA0750, MICAL2PV1, MICAL2PV2

Observed MW:95, 112 kDa

Uniprot ID:O94851

Reactivity:Human, Mouse, Rat

Tested Application:ELISA, IHC, IF

Recommended dilution:IHC: 1:20-1:200; IF: 1:20-1:200

Gene ID:9645

Research Area:Metabolism, Developmental biology