MGMT Antibody - Cat. #: CSB-PA563873

SKU: CSB-PA563873

Size :100ul

Clone Number:

Aliases:6 O methylguanine DNA methyltransferase antibody; 6-O-methylguanine-DNA methyltransferase antibody; Agat antibody; AGT antibody; AI267024 antibody; EC 2.1.1.63 antibody; Methylated DNA protein cysteine methyltransferase antibody; Methylated-DNA--protein-cysteine methyltransferase antibody; Methylguanine DNA methyltransferase antibody; MGC107020 antibody; MGMT antibody; MGMT_HUMAN antibody; O 6 methylguanine DNA alkyltransferase antibody; O 6 methylguanine DNA methyltransferase antibody; O-6-methylguanine-DNA methyltransferase antibody; O-6-methylguanine-DNA-alkyltransferase antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P16455

Immunogen:Synthesized peptide derived from internal of Human MGMT.

Raised in:Rabbit

Species Reactivity:Human, Rat

Tested Applications:ELISA, WB; WB:1:500-1:3000

Background:Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

Tano K., Proc. Natl. Acad. Sci. U.S.A. 87:686-690(1990).
Rydberg B., J. Biol. Chem. 265:9563-9569(1990).
Koike G., J. Biol. Chem. 265:14754-14762(1990)

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:MGMT

Research Areas:Epigenetics and Nuclear Signaling