MEIS2 Antibody, Biotin conjugated - Cat. #: CSB-PA013687LD01HU

SKU: CSB-PA013687LD01HU

Size :50ug

Clone Number:

Aliases:Homeobox protein Meis2 antibody; HsT18361 antibody; Meis (mouse) homolog 2 antibody; Meis homeobox 2 antibody; Meis homolog 2 antibody; Meis1 myeloid ecotropic viral integration site 1 homolog 2 (mouse) antibody; Meis1 myeloid ecotropic viral integration site 1 homolog 2 antibody; Meis1 related gene 1 antibody; Meis1 related protein 1 antibody; Meis1-related protein 1 antibody; MEIS2 antibody; MEIS2_HUMAN antibody; MGC2820 antibody; MRG1 antibody; TALE homeobox protein Meis2 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O14770

Immunogen:Recombinant Human Homeobox protein Meis2 protein (377-470AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3 and isoform 4 can bind to a EPHA8 promoter sequence containing the DNA motif 5\'-CGGTCA-3\'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5\'-TGACAG-3\'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription; isoform 5 cannot activate DRD1 transcription.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:MEIS2

Research Areas:Epigenetics and Nuclear Signaling; Neuroscience