MDM2 Monoclonal Antibody

SKU: BT-MCA4700

Size:100μL

Background:This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]

Research_area:Cell Biology

Target_protein:MDM2

applications:FCM

Reactivity:

Clonality:Monoclonal

Clone ID:4A8D12

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:MDM2

Immunogen:Purified recombinant fragment of human MDM2 (AA: 26-169) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):55.2kDa

UniProt accession:Q00987

Synonyms:HDMX, LSKB, hdm2, ACTFS

GeneID:4193