MCM3 Monoclonal Antibody

SKU: BT-MCA2085

Size:100μL

Background:The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Several transcript variants encoding different isoforms have been found for this gene.

Research_area:Epigenetics and Nuclear Signaling

Target_protein:MCM3

applications:WB, IHC, ICC, FCM

Reactivity:Human, Monkey, Rat

Clonality:Monoclonal

Clone ID:1D4A3

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:MCM3

Immunogen:Purified recombinant fragment of human MCM3 expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):91kDa

UniProt accession:P25205

Synonyms:HCC5, P1.h, RLFB, P1-MCM3

GeneID:4172