MAPK8 Monoclonal Antibody

SKU: BT-MCA3361

Size:100μL

Background:The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Research_area:Others

Target_protein:MAPK8

applications:WB, FCM

Reactivity:Human, Mouse

Clonality:Monoclonal

Clone ID:1E5

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:MAPK8

Immunogen:Purified recombinant fragment of human MAPK8 expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):48.3kDa

UniProt accession:P45983

Synonyms:JNK, JNK1, PRKM8, SAPK1, JNK-46, JNK1A2, SAPK1c, JNK21B1/2

GeneID:5599