MAPK10 Antibody, FITC conjugated - Cat. #: CSB-PA013449LC01HU

SKU: CSB-PA013449LC01HU

Size :50ug

Clone Number:

Aliases:c Jun kinase 3 antibody; c-Jun N-terminal kinase 3 antibody; cJun N terminal kinase 3 antibody; FLJ12099 antibody; FLJ33785 antibody; JNK3 alpha protein kinase antibody; JNK3 antibody; JNK3A antibody; MAP kinase 10 antibody; MAP kinase antibody; MAP kinase p49 3F12 antibody; MAPK 10 antibody; Mapk10 antibody; MGC50974 antibody; mitogen activated protein kinase 10 antibody; Mitogen-activated protein kinase 10 antibody; MK10_HUMAN antibody; p493F12 antibody; p54bSAPK antibody; PRKM10 antibody; protein kinase mitogen activated 10 antibody; SAPK1b antibody; Stress activated protein kinase 1b antibody; stress activated protein kinase beta antibody; Stress activated protein kinase JNK3 antibody; Stress-activated protein kinase JNK3 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P53779

Immunogen:Recombinant Human Mitogen-activated protein kinase 10 protein (133-316AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:

Background:Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:FITC

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:MAPK10

Research Areas:Neuroscience; Cancer; Signal transduction