M4K2 Polyclonal Antibody

SKU: BT-AP11029

Size:100μL

Background:The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. Alternative splicing results in multiple transcript variants.

Research_area:Signal transduction

Target_protein:MAP4K2

applications:WB, ELISA

Reactivity:Human, Rat, Mouse

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:Mitogen-activated protein kinase kinase kinase kinase 2

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):

UniProt accession:Human: Q12851; Mouse: Q61161

Synonyms:Mitogen-activated protein kinase kinase kinase kinase 2 ;EC 2.7.11.1;B lymphocyte serine/threonine-protein kinase;Germinal center kinase;GC kinase;MAPK/ERK kinase kinase kinase 2;MEK kinase

GeneID:Human: 5871