LRP6 Monoclonal Antibody

SKU: BT-MCA3360

Size:100μL

Background:This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.

Research_area:Signal transduction, Stem cells

Target_protein:LRP6

applications:FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:1A3F5

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:LRP6

Immunogen:Purified recombinant fragment of human LRP6 (AA: extra 1198-1370) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):180kDa

UniProt accession:O75581

Synonyms:ADCAD2, STHAG7

GeneID:4040