LAIR1 Antibody, HRP conjugated - Cat. #: CSB-PA012721LB01HU

SKU: CSB-PA012721LB01HU

Size :50ug

Clone Number:

Aliases:5133400O11Rik antibody; CD305 antibody; D7Bwg0421e antibody; hLAIR1 antibody; LAIR 1 antibody; LAIR-1 antibody; LAIR1 antibody; LAIR1 protein antibody; LAIR1_HUMAN antibody; Leukocyte associated Ig like receptor 1 antibody; Leukocyte associated immunoglobulin like receptor 1 antibody; Leukocyte-associated immunoglobulin-like receptor 1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q6GTX8

Immunogen:Recombinant Human Leukocyte-associated immunoglobulin-like receptor 1 protein (22-165AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:HRP

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:LAIR1

Research Areas:Immunology