KSR2 Antibody - Cat. #: CSB-PA012696LA01HU

SKU: CSB-PA012696LA01HU

Size :50ug

Clone Number:

Aliases:FLJ25965 antibody; hKSR 2 antibody; hKSR2 antibody; Kinase suppressor of Ras 2 antibody; KSR 2 antibody; Ksr2 antibody; KSR2_HUMAN antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q6VAB6

Immunogen:Recombinant Human Kinase suppressor of Ras 2 protein (159-296AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background:Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:KSR2

Research Areas:Signal transduction