Ki67 Monoclonal Antibody

SKU: AN005400L

Size::25μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles. Protected from prolonged exposure to light.

Shipping:The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies

Abbreviation:Ki67

Target Synonym:MIB;MKI;marker of proliferation Ki;Proliferation marker protein Ki;Antigen identified by monoclonal antibody Ki;PPP1R;MKI67;KIA;MIB-;MIB-1;PPP1R105;marker of proliferation Ki-67;Ki67;Antigen identified by monoclonal antibody Ki-67;Antigen Ki67;Antigen KI-67;Proliferation marker protein Ki-67;Antigen identified by monoclonal Ki 67;Antigen identified by monoclonal Ki-67;MIB 1;Proliferation related Ki 67 antigen;Protein phosphatase 1 regulatory subunit 105;RP11-380J17.2

Research Areas:Cell Biology;Neuroscience;Tags & Cell Markers;Cancer

Conjugation:Unconjugated

Host:Mouse

Species reactivity:Human

Application:IHC;IF

Isotype:IgG1

Clonality:Monoclonal

Clone NO.:3B7

UNIProt ID:P46013

Accession:

Background:Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly. Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface. Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility. Binds DNA, with a preference for supercoiled DNA and AT-rich DNA. Does not contribute to the internal structure of mitotic chromosomes. May play a role in chromatin organization. It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).

Concentration:1 mg/mL

Immunogen:Recombinant human Ki67 protein expressed by E.coli

Buffer:PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH 7.4

Purification method:Protein A/G Purification

Dilution:IHC 1:500-1:1000;IF 1:200-1:400

Calculated MW:

ObservedMW: