KDM2A antibody , Cat. # FNab04509

SKU: FNab04509

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono-and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis.

Immunogen:lysine(K)-specific demethylase 2A

Synonyms:CXXC8, FBL7, FBXL11, JHDM1A, KIAA1004

Observed MW:126 kDa

Uniprot ID:Q9Y2K7

Reactivity:Human, Mouse

Tested Application:ELISA, WB

Recommended dilution:WB: 1:500-1:2000

Gene ID:22992

Research Area:Epigenetics, Cancer, Metabolism