KCNQ2/3/4/5 rabbit pAb

SKU: ES6014

Size: 100μL

Source:Rabbit

Applications:IHC;IF;ELISA

Reactivity:Human;Mouse;Rat

Dilution:Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

Immunogen:The antiserum was produced against synthesized peptide derived from human Kv7.3/KCNQ3. AA range:191-240

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):

Human_gene_id:3786

Human_swiss_prot_no:O43526/O43525/P56696/Q9NR82

Subcellular_location:Cell membrane ; Multi-pass membrane protein .

Other_name:KCNQ2; Potassium voltage-gated channel subfamily KQT member 2; KQT-like 2; Neuroblastoma-specific potassium channel subunit alpha KvLQT2; Voltage-gated potassium channel subunit Kv7.2; KCNQ3; Potassium voltage-gated channel subfamily KQT me

Background:The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],