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Gene Bio Systems

ITGAV Antibody - Cat. #: CSB-PA011877LA01HU

ITGAV Antibody - Cat. #: CSB-PA011877LA01HU

CSB-PA011877LA01HU

¥61,200 JPY
¥61,200 JPY
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Size :50ug

Clone Number:

Aliases:antigen identified by monoclonal antibody L230 antibody; CD 51 antibody; CD51 antibody; DKFZp686A08142 antibody; Integrin alpha five antibody; integrin alpha V beta 3 antibody; Integrin alpha-5 antibody; integrin alpha-V antibody; Integrin alpha-V light chain antibody; integrin alphaVbeta3 antibody; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) antibody; ITAV_HUMAN antibody; ITGAV antibody; MSK 8 antibody; Msk8 antibody; Vitronectin receptor subunit alpha antibody; VNRA antibody; VTNR antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P06756

Immunogen:Recombinant Human Integrin alpha-V protein (775-885AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200

Background:The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 and ITGAV:ITGB6 act as a receptor for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:ITGAV

Research Areas:Cancer; Cardiovascular; Microbiology; Signal transduction; Stem cells

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