IL17A Polyclonal Antibody

SKU: E-AB-17917

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: IL17A

Target Synonym: CTLA 8;CTLA-8;CTLA8;Cytotoxic T lymphocyte associated antigen 8;Cytotoxic T lymphocyte associated protein 8;Cytotoxic T lymphocyte associated serine esterase 8;Cytotoxic T-lymphocyte-associated antigen 8;IL 17A;IL-17;IL-17A;IL17;IL17;Il17a;Interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8);Interleukin 17A;Interleukin-17A;Interleukin17;Interleukin17A;OTTHUMP00000016597;OTTMUSP00000046003

Research Areas: Cancer;Immunology

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human

Application: IHC

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: Q16552

Accession:

Background: IL17A,also named as IL-17,is a proinflammatory cytokine. IL-17,synthesized only by memory T cells and natural killer cells,has pleiotropic effects,mainly in the recruitment and activation of neutrophils. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2),as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis,psoriasis and multiple sclerosis. The IL-17 receptor is a type I transmembrane protein,that is widely expressed on epithelial cells,fibroblasts,B and T cells,and monocytic cells. In psoriatic skin lesions,both Th17 cells and their downstream effector molecules,e.g. IL-17 and IL-22,are highly increased.

Concentration: 1.14 mg/mL

Immunogen: Synthetic peptide of human IL17A

Buffer: PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Purification method: Antigen affinity purification

Dilution: IHC 1:30-1:150

Calculated MW:

ObservedMW: