IKBKE Monoclonal Antibody

SKU: BT-MCA2112

Size:100μL

Background:Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon.The transcription factor NFkB is retained in the cytoplasm in an inactive form by the inhibitory protein IkB. Activation of NFkB requires that IkB be phosphorylated on specific serine residues, which results in targeted degra-dation of IkB. IkB kinase a(IKKa), previously designated CHUK, interacts with IkB-aand specifically phosphorylates IkB-aon the sites that trigger its degradation, serines 32 and 36. The functional IKK complex contains three subunits, IKKa, IKKb and IKKg(also designated NEMO), and each appear to make essential contributions to IkB phosphorylation. IKK-i is a serine/threonine kinase that shares homology with IKKa and IKKb. IKK-i is pri-marily expressed in immune cells and is induced by lipopolysaccharide and by proinflammatory cytokines including TNFA, IL-1 and IL-6. Overexpression of IKK-i was shown to result in phosphorylation of IkBaon Ser32 and Ser36, and in NFkB activation, suggesting that IKK-i may act as an IkB kinase in the immune system.

Research_area:Signal transduction, Cell biology, Cardiovascular, Cancer, Immunology

Target_protein:IKBKE

applications:

Reactivity:Human

Clonality:Monoclonal

Clone ID:6B4B5

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:IKBKE

Immunogen:Purified recombinant fragment of IKBKE (aa1-257) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):

UniProt accession:Q14164

Synonyms:IKBKE

GeneID:9641