IFNL3 Antibody - Cat. #: CSB-PA810313ESR1HU

SKU: CSB-PA810313ESR1HU

Size :50ul

Clone Number:

Aliases:Cytokine ZCYTO22 antibody; IFN-lambda-3 antibody; IFN-lambda-4 antibody; IL-28B antibody; IL-28C antibody; IL28B antibody; IL28B_HUMAN antibody; IL28C antibody; Interferon lambda-3 antibody; Interferon lambda-4 antibody; interleukin 28B (interferon; lambda 3) antibody; Interleukin 28C antibody; Interleukin-28B antibody; Interleukin-28C antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q8IZI9

Immunogen:Recombinant Human Interferon lambda-3 protein (22-196AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background:Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:IFNL3

Research Areas:Immunology; Signal transduction