IFITM3 Polyclonal Antibody

SKU: D-AB-10162L

Size::25μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:IFITM3

Target Synonym:1 8U;Fragilis;IFITM3;IFM3;Interferon induced transmembrane protein 3 (1 8U);Interferon Induced Transmembrane Protein 3;Interferon inducible;Interferon inducible protein 1 8U;Interferon Inducible Protein 15;Interferon Inducible Protein Homolog;Interferon-induced transmembrane protein 3;Interferon-inducible protein 1-8U;IP15

Research Areas:Cancer;Developmental Biology;Stem Cells

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB;IHC;IF

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:P26376

Accession:

Background:IFITM3,also named as interferon-inducible protein 1-8U,belongs to the CD225 family. It is IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens,namely influenza A H1N1 virus,West Nile virus (WNV),and dengue virus,by inhibiting the early steps of replication. IFITM3 is identified as interferon-induced cellular proteins that restrict infections by retroviruses and filoviruses and of influenza virus and flaviviruses,respectively. IFITM3,the most potent antiviral IFITM,was found to inhibit an uncharacterized early infectious event after VSV endocytosis,but before primary transcription of its viral genome. IFITM proteins are viral restriction factors that can inhibit infection mediated by the influenza A virus (IAV) hemagglutinin (HA) protein. They differentially restrict the entry of a broad range of enveloped viruses,and modulate cellular tropism independently of viral receptor expression. This antibody recognizes both IFITM2 and IFITM3.

Concentration:1 mg/mL

Immunogen:Recombinant Rat IFITM3 protein expressed by E.coli

Buffer:PBS with 0.02% sodium azide,1% protective protein and 50% glycerol,pH7.4

Purification method:Antigen Affinity Purification

Dilution:WB 1:1000-1:2000;IHC 1:50-1:200;IF 1:100-1:400

Calculated MW:15 kDa

ObservedMW:15 kDa