HYOU1 Rabbit Polyclonal Antibody

SKU: BT-AP10525

Size:100μL

Background:The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction| resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis| it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors| especially in breast tumors| and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site| resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein| which is only 3 amino acids shorter than the mature protein in the ER| is thought to have a housekeeping function in the cytosol. In rat| this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. Alternative splicing results in multiple transcript variants.

Research_area:Cancer; Cardiovascular; Epigenetics and nuclear signaling; Metabolism; Neuroscience; Signal transduction

Target_protein:HYOU1

applications:WB

Reactivity:Human, Mouse, Rat

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:HYOU1

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):109890

UniProt accession:Human: Q9Y4L1; Mouse: Q9JKR6; Rat: Q63617

Synonyms:HYOU1

GeneID:Human: 10525; Mouse: 12282; Rat: 192235