Human uPA/PLAU/URK EZ-Set™ ELISA Kit (DIY Antibody Pairs)

SKU: EZ0535

Size: 5 plates/kit

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: PLAU

Specificity: Natural and recombinant human Upa

Background: Plasminogen activator,urokinase (PLAU, uPA) converts plasminogen to plasmin. Plasmin is involved in processing of amyloid precursor protein and degrades secreted and aggregated amyloid-beta, a hallmark of Alzheimer disease (AD). Urokinase has a molecular mass of about 54 kD and is composed of 2 disulfide-linked chains, A and B, of molecular masses 18 kD and 33 kD, respectively. It localized on 10q24. uPA facilitates cell migration by localizing proteolisys on the cell surface and by inducing intracellular signalling pathways. In human vascular smooth muscle cell (VSMC), uPA stimulates migration via the uPA receptor (uPAR) signalling complex containing TYK2 and phosphatidylinositol 3-kinase (PI3-K).

Immunogen: Expression system for standard: NS0; Immunogen sequence: M1-L431

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Reconstitution:

Reference:

Uniprot ID: P00749

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

Isotype:

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Gene ID: 5328

Protein Name: Urokinase-type plasminogen activator

Gene Full Name: plasminogen activator, urokinase

Synonyms: ATF; PLAU; U plasminogen activator; uPA; uPA/Urokinase; URK