Human Tyrosyl-DNA Phosphodiesterase 1, TDP1 ELISA Kit

SKU: E6368Hu

Size:96 Tests-1 Kit

Background:DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate.

Research_area:Others

Applications:ELISA

Target_protein:TDP1

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.85ng/L

Detection range:20-7000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Tyrosyl-DNA Phosphodiesterase 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9NUW8

MASS(Da):68,420

GeneID:55775

Synonyms:TDP1;Tyr-DNA phosphodiesterase 1;Tyrosyl-DNA phosphodiesterase 1

Gene names:TDP1

Standard solution:8000ng/L