Human Tyrosine-protein Kinase Yes, YES1 ELISA Kit

SKU: E6365Hu

Size:96 Tests-1 Kit

Background:Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis.

Research_area:Others

Applications:ELISA

Target_protein:YES1

Reactivity:Human

Assay type:Sandwich

Sensitivity:7.75ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Tyrosine-protein kinase Yes

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P07947

MASS(Da):60,801

GeneID:7525

Synonyms:c-yes;HsT441;P61-YES;Proto-oncogene c-Yes;Tyrosine-protein kinase Yes;Yes;YES1

Gene names:YES1

Standard solution:3200ng/L