Human Twist-related Protein 1, TWIST1 ELISA Kit

SKU: E3531Hu

Size:96 Tests-1 Kit

Background:Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer (By similarity).

Research_area:Others

Applications:ELISA

Target_protein:TWIST1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.02ng/ml

Detection range:0.05-20ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Twist-Related Protein 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q15672

MASS(Da):20,954

GeneID:7291

Synonyms:bHLHa38;Class A basic helix-loop-helix protein 38;H-twist;TWIST 1;TWIST1;Twist-related protein 1

Gene names:TWIST1

Standard solution:24ng/ml