Human Tumor Necrosis Factor Receptor Superfamily Member 21, TNFRSF21 ELISA Kit

SKU: E3346Hu

Size:96 Tests-1 Kit

Background:Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid Peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation.

Research_area:Cell Biology

Applications:ELISA

Target_protein:TNFRSF21

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.023ng/ml

Detection range:0.05-10ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Tumor Necrosis Factor Receptor Superfamily Member 21

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O75509

MASS(Da):71,845

GeneID:27242

Synonyms:CD antigen CD358;Death receptor 6;TNFRSF 21;TNFRSF21;Tumor necrosis factor receptor superfamily member 21

Gene names:TNFRSF21

Standard solution:12.8ng/ml