Human Transcription Factor Sox-6, SOX6 ELISA Kit

SKU: E6293Hu

Size:96 Tests-1 Kit

Background:Transcription factor that plays a key role in several developmental processes, including neurogenesis, chondrocytes differentiation and cartilage formation. Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX5, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene, and is thereby involved in the differentiation of oligodendroglia in the developing spinal tube. Binds to the gene promoter of MBP and acts as a transcriptional repressor.

Research_area:Neuroscience

Applications:ELISA

Target_protein:SOX6

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.45ng/L

Detection range:20-6000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Transcription Factor Sox-6

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P35712

MASS(Da):91,921

GeneID:55553

Synonyms:SOX 6;SOX6;Transcription factor SOX-6

Gene names:SOX6

Standard solution:6400ng/L