Human Torsin 1A, TOR1A ELISA Kit

SKU: E2608Hu

Size:96 Tests-1 Kit

Background:Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular trafficking and may regulate the subcellular location of multipass membrane proteins such as the dopamine transporter SLC6A3, leading to the modulation of dopamine neurotransmission. In the endoplasmic reticulum, plays a role in the quality control of protein folding by increasing clearance of misfolded proteins such as SGCE variants or holding them in an intermediate state for proper refolding. May have a redundant function with TOR1B in non-neural tissues.

Research_area:Others

Applications:ELISA

Target_protein:TOR1A

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.022ng/ml

Detection range:0.05-30ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Torsin 1A

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O14656

MASS(Da):37,809

GeneID:1861

Synonyms:Dystonia 1 protein;TOR1A;Torsin ATPase-1A;Torsin family 1 member A;Torsin-1A

Gene names:TOR1A

Standard solution:32ng/ml