Human Toll-like Receptor 8, TLR8 ELISA Kit

SKU: E0375Hu

Size:96 Tests-1 Kit

Background:Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed: 25297876, PubMed: 32433612). Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially processed by RNASET2 (PubMed: 31778653). Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction (PubMed: 23520111, PubMed: 25599397, PubMed: 26929371). In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce proinflammatory cytokines and interferons, respectively (PubMed: 16737960, PubMed: 17932028, PubMed: 29155428).

Research_area:Immunology

Applications:ELISA

Target_protein:TLR8

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.3ng/ml

Detection range:0.5-100ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Toll-Like Receptor 8

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9NR97

MASS(Da):119,828

GeneID:51311

Synonyms:CD antigen CD288;TLR 8;TLR8;Toll-like receptor 8

Gene names:TLR8

Standard solution:128ng/ml