Human TNFRSF9/4-1BB ELISA Kit PicoKine®

SKU: EK0988

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: TNFRSF9

Specificity: Natural and recombinant human TNFRSF9

Background: CD137 is a member of the tumor necrosis factor (TNF) receptor family. Its alternative names are tumor necrosis factor receptor superfamily member 9 (TNFRSF9), 4-1BB and induced by lymphocyte activation (ILA). CD137 gene was localized to chromosome 1p36.Members of this receptor family and their structurally related ligands are important regulators of a wide variety of physiological processes and play an especially important role in the regulation of immune responses. CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. The best characterized activity of CD137 is its costimulatory activity for activated T cells. Crosslinking of CD137 enhances T cell proliferation, IL-2 secretion survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice.

Immunogen: Expression system for standard: NS0; Immunogen sequence: L24-Q186

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Reference:

Uniprot ID: Q07011

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 3604

Protein Name: Tumor necrosis factor receptor superfamily member 9

Gene Full Name: TNF receptor superfamily member 9

Synonyms: 4 1BB; 4 1BB ligand receptor; CD137; CDw137; ILA; T cell antigen 4 1BB homolog; T cell antigen ILA; TNFRSF9