Human TNFRSF13B/TACI ELISA Kit PicoKine®

SKU: EK0986

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: TNFRSF13B

Specificity: Natural and recombinant human TNFRSF13B

Background: Tumor necrosis factor receptor superfamily member 13B, also known as TNFRSF13B or more commonly as TACI, is a transmembrane receptor protein found predominantly on the surface of B cells, which are an important part of the immune system. TACI controls T cell-independent B cell antibody responses, isotype switching, and B cell homeostasis. TACI is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It was originally discovered because of its ability to interact with calcium-modulator and cyclophilin ligand (CAML). TACI was later found to play a crucial role in humoral immunity by interacting with two members of the TNF family: BAFF and APRIL. These proteins signal through TACI inducing activation of several transcription factors including NFAT, AP-1, and NF-kappa-B which then modulate cellular activities. Defects in the function of TACI can lead to immune system diseases.

Immunogen: Expression system for standard: NS0; Immunogen sequence: S2-T166

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Uniprot ID: O14836

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 23495

Protein Name: Tumor necrosis factor receptor superfamily member 13B

Gene Full Name: TNF receptor superfamily member 13B

Synonyms: TNF receptor superfamily member 13B; CD267; CVID; CVID2; IGAD2; RYZN; TACI; TNFRSF14B; TNFRSF13B