Human TIM-3/HAVCR2 PicoKine® Quick ELISA Kit

SKU: FEK1644

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: HAVCR2

Specificity: Natural and recombinant human TIM-3

Background: Hepatitis A virus cellular receptor 2 (HAVCR2), also known as T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), is a protein that in humans is encoded by the HAVCR2 gene. The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.

Immunogen: Expression system for standard: NS0; Immunogen sequence: S22-G202

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Reference:

Uniprot ID: Q8TDQ0

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 84868

Protein Name: Hepatitis A virus cellular receptor 2

Gene Full Name: hepatitis A virus cellular receptor 2

Synonyms: CD366; HAVcr 2; HAVCR2; KIM 3; T cell membrane protein 3; Tim 3; TIM3; TIM-3; TIMD 3; TIMD3