Human TGFBR3/Tgf Beta Riii PicoKine® Quick ELISA Kit

SKU: FEK1383

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: TGFBR3

Specificity: Natural and recombinant human TGFBR3

Background: Betaglycan also known as Transforming growth factor beta receptor III (TGFBR3), is a cell- surfacechondroitin sulfate / heparan sulfate proteoglycan >300 kDa in molecular weight. Betaglycan binds to various members of the TGF-beta superfamily of ligands via its core protein, and bFGF via its heparan sulfate chains. It is not involved ly in TGF-beta signal transduction but by binding to various member of the TGF-beta superfamily at the cell surface it acts as a reservoir of ligand for TGF-beta receptors. By cDNA array and immunohistochemistry analyses, it is found that TGFBR3 expression is lost in most breast cancers examined in association with loss of heterozygosity of the TGFBR3 locus. TGFBR3 expression decreased during breast cancer progression, and low levels predicted decreased recurrence-free survival in patients. Loss of TGFBR3 through allelic imbalance is a frequent genetic event during breast cancer development that increases metastatic potential. Also, TGFBR3 can localize transformation in the heart and play an essential, nonredundant role in TGF-beta signaling.

Immunogen: Expression system for standard: NS0; Immunogen sequence: G21-D781

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Reference:

Uniprot ID: Q03167

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 7049

Protein Name: Transforming growth factor beta receptor type 3

Gene Full Name: transforming growth factor beta receptor 3

Synonyms: betaglycan; BGCAN; TGF beta receptor type 3; TGF beta receptor type III; TGF-beta Receptor III; TGFBR3; TGFBR3-Specific; TGFR 3; TGFβRIII