Human Telomeric Repeat Binding Factor 2 Interacting Protein,TERF2IP ELISA KIT

SKU: E6468Hu

Size:96 Tests-1 Kit

Background:Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes. {ECO:0000269|PubMed:16166375, ECO:0000269|PubMed:19763083}.

Research_area:

Applications:ELISA

Target_protein:TERF2IP

Reactivity:Human

Assay type:Sandwich

Sensitivity:4.96ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Telomeric Repeat Binding Factor 2 Interacting Protein

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9NYB0

MASS(Da):44260

GeneID:54386

Synonyms:TERF2IP DRIP5 RAP1 PP8000

Gene names:TERF2IP

Standard solution:2400ng/L