Human Telomeric Repeat-binding Factor 1, TERF1 ELISA Kit

SKU: E6257Hu

Size:96 Tests-1 Kit

Background:Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.

Research_area:Epigenetics and Nuclear Signaling

Applications:ELISA

Target_protein:TERF1

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.63ng/L

Detection range:20-3800ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Telomeric Repeat-Binding Factor 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P54274

MASS(Da):50,246

GeneID:7013

Synonyms:NIMA-interacting protein 2;Telomeric protein Pin2/TRF1;Telomeric repeat-binding factor 1;TERF 1;TERF1;TTAGGG repeat-binding factor 1

Gene names:TERF1

Standard solution:4000ng/L