Human SPHK1/Sphingosine Kinase 1 ELISA Kit PicoKine®

SKU: EK1501

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: SPHK1

Specificity: Natural and recombinant human SPHK1

Background: Sphingosine kinase 1 is an enzyme that in humans is encoded by the SPHK1 gene. The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1- phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Immunogen: Expression system for standard: NS0; Immunogen sequence: M1-L384

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Reconstitution:

Reference:

Uniprot ID: Q9NYA1

Host:

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Conjugate:

Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

Isotype:

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Gene ID: 8877

Protein Name: Sphingosine kinase 1

Gene Full Name: sphingosine kinase 1

Synonyms: SK 1; sphingosine kinase 1; SPHK; SPHK1; SPHK1 phopho; SPK; SPK 1