Human Sp100 Nuclear Antigen,Sp100 ELISA KIT

SKU: E4028hu

Size:96 Tests-1 Kit

Background:Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation. {ECO:0000269|PubMed:11909962, ECO:0000269|PubMed:14647468, ECO:0000269|PubMed:15247905, ECO:0000269|PubMed:15592518, ECO:0000269|PubMed:15767676, ECO:0000269|PubMed:16177824, ECO:0000269|PubMed:17245429, ECO:0000269|PubMed:21274506, ECO:0000269|PubMed:21880768}.

Research_area:

Applications:ELISA

Target_protein:SP100

Reactivity:Human

Assay type:Sandwich

Sensitivity:18.62pg/ml

Detection range:37.5-2400pg/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Sp100 Nuclear Antigen

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P23497

MASS(Da):100417

GeneID:6672

Synonyms:SP100

Gene names:SP100

Standard solution:4800pg/ml