Human Somatostatin Receptor 2, SSTR2 ELISA Kit

SKU: E3391Hu

Size:96 Tests-1 Kit

Background:Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium Channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.

Research_area:Neuroscience

Applications:ELISA

Target_protein:SSTR2

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.28ng/ml

Detection range:0.5-150ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Somatostatin Receptor 2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P30874

MASS(Da):41,333

GeneID:6752

Synonyms:Somatostatin receptor type 2;SRIF-1;SS2R;SS2-R;SS-2-R;SSTR 2;SSTR2

Gene names:SSTR2

Standard solution:160ng/ml