Human soluble Interleukin-1 receptor type 1,sIL1R1 ELISA KIT

SKU: E0206Hu

Size:96 Tests-1 Kit

Background:Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (PubMed:10653850). {ECO:0000269|PubMed:10653850, ECO:0000269|PubMed:10671496}.

Research_area:

Applications:ELISA

Target_protein:IL1R1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.01ng/ml

Detection range:0.05-15ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:soluble interleukin-1 receptor 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P14778

MASS(Da):65402

GeneID:3554

Synonyms:IL1R1 IL1R IL1RA IL1RT1

Gene names:IL1R1

Standard solution:16ng/ml