Human Shc-Transforming Protein 1, SHC1 ELISA Kit

SKU: E6169Hu

Size:96 Tests-1 Kit

Background:Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.

Research_area:Others

Applications:ELISA

Target_protein:SHC1

Reactivity:Human

Assay type:Sandwich

Sensitivity:7.15ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Shc-Transforming Protein 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P29353

MASS(Da):62,822

GeneID:6464

Synonyms:SH2 domain protein C1;SHC 1;SHC1;SHC-transforming protein 1;SHC-transforming protein 3;SHC-transforming protein A;Src homology 2 domain-containing-transforming protein C1

Gene names:SHC1

Standard solution:3200ng/L