Human Sestrin 1, SESN1 ELISA Kit

SKU: E2522Hu

Size:96 Tests-1 Kit

Background:Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed: 25263562, PubMed: 26449471). This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed: 23274085). May have an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed: 15105503). However, this could not be confirmed (By similarity).

Research_area:Cell Biology

Applications:ELISA

Target_protein:SESN1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.13ng/ml

Detection range:0.2-65ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Sestrin 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9Y6P5

MASS(Da):56,557

GeneID:27244

Synonyms:p53-regulated protein PA26;SESN 1;SESN1;Sestrin-1

Gene names:SESN1

Standard solution:72ng/ml